Cryo-EM structure of 5-HT1AR-GoA in complex with gepirone

Cryo-EM structure of 5-HT1AR-GoA in complex with gepirone Descriptor: (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, CHOLESTEROL, Gepirone, ... Authors: Wang, C, Cao, C. Deposit date: 2025-06-19 Release date: 2025-11-12 Last modified: 2026-04-01 Method: ELECTRON MICROSCOPY (2.69 Å) Cite: Pathway-selective 5-HT 1A R agonist as a rapid antidepressant strategy. Cell, 188, 2025