A Set of Nonpolar Thymidine Nucleoside Analogues with Gradually Increasing Size
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https://figshare.com/articles/dataset/A_Set_of_Nonpolar_Thymidine_Nucleoside_Analogues_with_Gradually_Increasing_Size/3318913
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资源简介：
We describe a series of nonpolar nucleoside analogues having similar shapes and gradually increasing size. The structure of the nucleobase
thymine was mimicked with toluene derivatives, replacing O2/O4 with hydrogen, fluorine, chlorine, bromine, and iodine. Glycosidic bonds
were formed by reactions of lithiated 2,4-dihalotoluenes with a deoxyribonolactone derivative. Structural analysis by NMR showed similar
conformations across the series. The compounds are useful for study of the biological recognition of nucleotides and nucleic acids.
创建时间：
2004-10-28
