Potential Biomarkers and their Metabolic Pathway.

aMetabolites identified by retention time and MS2 spectrum of an authentic standard;bMetabolites putatively annotated.c“↑” and “↓” represent the compound is up- and down-regulated in model groups (MMI, PTU and Thyroidectomy-induced hypothyroid groups) compared with the control and sham groups, respectively.dVIP, variable importance on projection. VIP values ≥1.5 are considered significantly changed metabolites.eThe fold change (FC) of relative amounts of the model groups (MMI, PTU and Thyroidectomy-induced hypothyroid groups) compared with the control and sham groups, respectively.fThe p value was calculated by one-way ANOVA and then by the Tukey post hoc test for comparisons of multiple groups (after correction for multiple hypothesis testing and false discovery rate