Toll-Like Receptor 7 Agonist GS-9620 Induces Prolonged Inhibition of HBV in Human Hepatocytes via a Type I Interferon-Dependent Mechanism

TLR7 induced transcriptional change in HBV-infected primary human hepatocytes Overall design: RNA-Seq was conducted in two independent primary human hepatocyte (PHH) donors. After day 13 post-infection, primary human hepatocytes (PHH) were infected with HBV and treated with GS-9620, with media from human peripheral blood mononuclear cells (PBMCs) treated with GS-9620 (GS-9620 conditioned media; GS-9620-CM)