Outcomes of intrahepatic cholangiocarcinoma specific CRISPR screening in vivo [mouse exome]

We report the genertion of a gRNA library that induces mutations often found in intrahepatic cholangiocarcinoma. We use this to screen in vivo mutations that when lost act synergistically with mutant Ras. Specifically KrasG12D and NrasG12V. We have included exome sequencing of these tumours in this data set. Whole exome from mouse intrahepatic cholangiocarcinoma containing a range of mutations