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Basic model of differentiation hierarchy of normal and leukemic cells.

Figshare2015-12-02 更新2026-05-11 收录

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Basic model of differentiation hierarchy of normal and leukemic cells.

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2015-12-02

白血病机制研究

转录因子功能分析

Hypomorphic mutations of the transcription factor PAX5 occur in one third of B-progenitor acute lymphoblastic leukemias (B-ALLs). To identify PAX5-regulated genes in B-ALL, here we employ inducible ex

NIAID Data Ecosystem60

Genome-wide binding of GFI1 in NB4 cells

转录因子结合位点分析

白血病机制研究

ChIP-seq analyses were conducted in NB4 cells with two antibodies against GFI1. Identification of GFI1 binding peaks in acute promyelocytic leukemia derived NB4 cells. Two antibodies against different

NIAID Data Ecosystem50

Mouse spleen: Histone modification patterns in spleens from wild type and leukemic mice

白血病机制研究

表观遗传学分析

ChIP-Seq for H3K4me3 and H3K27me3 in wild type spleens and spleens from mice having deletion of RBP-J in cells of the renin lineage, which results in B-cell leukemia. Overall design: Examination of 2

NIAID Data Ecosystem30

Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia. Mus musculus

白血病机制研究

癌症靶向治疗

Here we show that pan-haematopoietic ERG expression driven by the Vav promoter induces an early progenitor myeloid leukemia in transgenic mice. Integrated genome-scale analysis of gene expression and

NIAID Data Ecosystem60

CCAAT/enhancer-binding protein alpha (CEBPA) gene haploinsufficiency does not alter hematopoiesis or induce leukemia in Lck-CALM/AF10 transgenic mice

白血病机制研究

造血系统

Although rare, CALM/AF10 is a chromosomal rearrangement found in immature T-cell acute lymphoblastic leukemia (T-ALL), acute myeloid leukemia, and mixed phenotype acute leukemia of T/myeloid lineages

Figshare2019-05-01 更新40

Basic model of differentiation hierarchy of normal and leukemic cells.

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