RAS GO enrichment and KEGG pathway (xlsx 45âkb). GO and KEGG pathway enrichment of RASEs (regulated alternative splicing events) between CRKL-knockdown and control samples of HeLa cells. (XLSX 44 kb
RNA-sequencing data from HEK293T and HAP1 cell models: Hek293T (SF3B1-K700E, SF3B1-WT, SUGP1-KD and siContol), HAP1 CRISPR-isogenic cell lines WT and SUGP1-P636L In cellulo examination of SUGP1 loss,
Aberrant alternative splicing, prevalent in cancer, impacts various cancer hallmarks involving proliferation, angiogenesis, and invasion. Splicing disruption often results from somatic point mutations
