OXA-58-NA-1-157 2.5 hour complex

OXA-58-NA-1-157 2.5 hour complex Descriptor: (5R)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-5-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase Authors: Smith, C.A, Maggiolo, A.O, Toth, M, Vakulenko, S.B. Deposit date: 2024-08-19 Release date: 2024-12-11 Last modified: 2024-12-25 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Decarboxylation of the Catalytic Lysine Residue by the C5 alpha-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the OXA-58 Carbapenemase. Acs Infect Dis., 10, 2024