Results of the nonlinear regression analyses of dose-response-curves of intracellular free calcium in response to extracellular calcium.

wt, wild type CaSR; EC50 [Ca2+]o, extracellular calcium concentration giving half maximal response determined from normalized data; 95% CI, 95% confidence interval. The p-values for the regression fit was obtained by comparing nested models with EC50 and maximum response common between mutant and wildtype or allowed to be different. TM7, transmembrane domain 7; ECD, extracellular domain; ECL3, extracellular loop 3.Results of the nonlinear regression analyses of dose-response-curves of intracellular free calcium in response to extracellular calcium.