Additional file 2: of Prenatal arsenic exposure alters the placental expression of multiple epigenetic regulators in a sex-dependent manner

Associations of candidate gene expression in fetal placenta with maternal U-As. Multivariable linear regression analysis was performed to determine the association between log-transformed maternal U-As and log-transformed fetal placental expression of epigenetic candidate genes, in A) the unstratified cohort, B) males, and C) females. Analyses were adjusted for maternal age at enrollment. P values before and after FDR adjustment are shown (columns C-D). The effect of adjustment for urinary creatinine was also determined, by comparing the standardized beta values obtained from the subset of participants for which urinary creatinine data were available (“standardized_subset_beta”, column P) with the equivalent values after adjustment for urinary creatinine (“standardized_subset_beta”, column Q). Results of goodness-of-fit tests are also shown (columns S-T). (XLSX 124 kb)