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Antibody repertoire RNA-seq throughout key stages of mouse B-cell development (pre-B-cells, naive B cells, plasma cells)

ChEBI2017-03-28 更新2026-07-12 收录

B细胞发育

免疫组库测序

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-5349 数据链接链接失效反馈

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资源简介：

Antibody repertoire RNA-seq throughout key stages of mouse B-cell development (pre-B-cells, naive B cells, plasma cells)

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创建时间：

2017-03-28

B细胞发育

信号转导分析

We examined the global gene expression profile of PLCγ1/PLCγ2 double-deficient CLPsand B cell progenitors by RNA-seq analysis. Overall design: CLPs (Lin-IL-7R+) and B cell progenitors (B220+IgM-IL-7R+

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The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement. The spliceosome component Usp39 controls B cell development by regulating immunoglobulin gene rearrangement

B细胞发育

剪接体功能

The spliceosome is a large ribonucleoprotein complex responsible for pre-mRNA splicing and genome stability maintenance. Disruption of the spliceosome activity may lead to developmental disorders and

NIAID Data Ecosystem60

Maternal Schistosomiasis Bone Marrow B Cell V(D)J scRNAseq

B细胞发育

寄生虫免疫学

We performed V(D)J scRNA sequencing to find transcriptional and B cell receptor repertoire differences in maturing B cells of mice born to mothers chronically infected with Schistosoma mansoni. Cite-s

NIAID Data Ecosystem50

A missense mutation in AIOLOS causes B cell deficiency by interfering with IKAROS. A missense mutation in AIOLOS causes B cell deficiency by interfering with IKAROS

B细胞发育

转录因子功能干扰

A missense mutation (G158R) in Ikzf3 gene resulted in defective generation of B cells in mice. Pre-B cells were profoundly decreased in homozygous mutant mice. Heterozygous mutant mice showed milder B

NIAID Data Ecosystem60

Polypyrimidine tract binding proteins are essential for B cell development. Polypyrimidine tract binding proteins are essential for B cell development

B细胞发育

转录调控

During B cell development, recombination of immunoglobulin loci is tightly coordinated with the cell cycle to avoid unwanted rearrangements of other genomic locations. Several factors have been identi

NIAID Data Ecosystem50

Antibody repertoire RNA-seq throughout key stages of mouse B-cell development (pre-B-cells, naive B cells, plasma cells)

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