Linear mixed effect model analysis of SME1 and SME2 and tau, p-tau, and AB42 in the longitudinal cohort, Cohort-2.

SME1: dMS feature ID 751080736 at m/z = 639.63 Da; z = 3; Mo = 1915.85 Da; AA sequence = NSEPQDEGELFQGVDPR; unique to protein sequence IPI00289501.2 Neurosecretory protein VGF.
SME2 = dMS feature ID751082515 at m/z = 635.98 Da, z = 3, Mo = 1903.90 Da, AA sequence = VAELEHGSSAYSPPDAFK, unique to protein sequence IPI00334238.1 Neuronal pentraxin receptor 1 (NPTXR).
Serial CSF samples were taken annually. Log area under the curve (AUC) intensity values for SME1 and SME2 measured by dMS and ELISA measurements for tau, p-tau, and AB42 were analyzed in the mixed-effect model described in methods.