Unprecedented SnCl<sub>2</sub>-Mediated Cyclization of Nitro Arenes via N−N Bond Formation<sup>†</sup>
收藏NIAID Data Ecosystem2026-03-06 收录
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A mild, efficient, one-pot protocol for the cyclization of nitro-aryl substrates using SnCl2 has been described. The mechanistic course of the reaction suggests the involvement of a hydroxylamine intermediate leading to an intramolecular cyclization via N−N bond formation. The versatility of the methodology has been demonstrated by using two nitro-aryl substrates derived from dihydroisoquinolines and dihydro-β-carbolines. The intramolecular cyclization led to the formation of indazoles in high yields and purities.
创建时间：
2016-05-05
