Proteogenomic analysis of chemo-refractory high grade serous ovarian cancer (PTRC-HGSOC)

In our study, we have generated proteomic and genomic (RNA sequencing and whole genome sequencing) profiles from high grade serous ovarian cancer (HGSOC) tumor biopsies. All biospecimens are formalin-fixed, parrafin-embedded (FFPE) tissues and annotated for patient sensitivity to platinum chemotherapy (refractory or sensitive). For all 174 tumors that were analyzed, we have H and imaged the first and last sections (“bookend”) cut from each FFPE block to allow study of tumor pathology. These H pathology images are uploaded in this dataset. The bookend FFPE slides were cut at 4 μm thickness using a microtome and mounted on glass slides (Leica Biosystems Cat# 3800040) for H staining. Digital images of the H slides were recorded using a ScanScope AT Slide Scanner (Leica Aperio Technologies, Vista, CA, USA) under 20X objective magnification (0.5 μm resolution). Images were analyzed by HALO Image Analysis Platform software (Indicta Labs, Albuquerque, New Mexico, USA).