Viral and Cellular N6-methyladenosine (m6A) Epitranscriptomes in KSHV Life Cycle

Tan et al. discovered abundant conserved N6-methyladenosine (m6A) modifications on KSHV transcripts during latent and productive infection in different cell types. They also show that m6A readers YTHDF2 and YTHDF3 mediate KSHV replication, and KSHV optimizes both phases of viral replication by reprograming cellular epitranscriptome to regulate distinct signaling pathways.Tan等人在不同细胞类型的潜伏感染与增殖性感染阶段中，于卡波西肉瘤相关疱疹病毒（KSHV）的转录本上发现了大量保守的N6-甲基腺嘌呤（N6-methyladenosine，m6A）修饰。该团队同时证实，m6A阅读器YTHDF2与YTHDF3可介导KSHV的复制；且KSHV通过重编程细胞表观转录组以调控不同信号通路，进而优化病毒复制的两个阶段。