Andes Orthohantavirus (ANDV) Emergency Response Knowledge Graph

This document presents an emergency response knowledge graph for Andes orthohantavirus (ANDV). The knowledge graph delineates the continuous pathophysiological continuum of ANDV infection, integrating multi-modal biochemical markers, longitudinal viral mutational trajectories, and macroscopic clinical symptom transitions. It aggregates high-resolution structural data, such as the pre-fusion stabilization of the Gn/Gc glycoprotein tetramer, with molecular mechanisms of viral entry, including interactions with beta-3 integrins and Protocadherin-1 (PCDH1) receptors. Furthermore, the framework incorporates intracellular replication dynamics, detailing the nucleocapsid (N) protein-mediated immune evasion pathways and the Large (L) protein endonuclease cap-snatching processes. The knowledge base systematically links these viral pathogenesis pathways with targeted pharmacological interventions, specifying synergistic multi-target combinations of macromolecular neutralizing antibodies and small-molecule inhibitors. By establishing a continuous analytical baseline across micro-biochemical variations and macroscopic systemic manifestations, this emergency response architecture supports rapid diagnostic screening, continuous cohort stratification, and therapeutic deployment during ANDV outbreaks.