Dataset for article "Molecular solutions to RNA self-cleavage are numerous yet evolution favors a few"

The Data.zip file consists of the following directories. Sparse-tiling: Sequences of all 141,993 sparsely tiled circular RNAs and the cleavage scores of 720,000 tiles derived from them. See _Notes.txt for a detailed description of each file. Dense-tiling: Sequences of all 12,370 densely tiled circular RNAs and the cleavage scores of 717,579 tiles derived from them. See _Notes.txt for a detailed description of each file. DMS: Cleavage scores of the 105 wild-type ribozymes and their 84,396 mutants. See _Notes.txt for a detailed description of each file. Clip: Sequences and cleavage scores of all putative clip ribozymes identified and assayed. See _Notes.txt for a detailed description of each file. Miscellaneous: Clip covariance models and the expression vector sequence. The Scripts.zip file contains the scripts for analyzing the cleavage score measurements. They are categorized by the dataset analyzed (Dense-tiling, DMS, and Clip). Those in Base-scripts are required for all three types of analyses. See the comments inside each script for a detailed description. Raw sequencing reads and the scripts for processing them into cleavage scores are not provided here because of size restrictions. They are available upon request.