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Digoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORγt activity

ChEBI2011-03-28 更新2026-07-21 收录

Th17细胞免疫

RORγt靶向药物

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-27241 数据链接链接失效反馈

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资源简介：

Digoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORγt activity

应用场景：

创建时间：

2011-03-28

Th17细胞免疫

植物提取物药效

Naive CD4+ T cells differentiate into effector (Th1, Th2, Th17) cells and immunosuppressive (Treg) cells upon antigenic stimulation in the presence of a specific cytokine milieu. The T cell in vitro c

NIAID Data Ecosystem90

Synthesis and biological evaluation of new triazolo and imidazolopyridine RORgt inverse agonists

RORγt靶向药物

免疫调节剂发现

Synthesis and biological evaluation of new triazolo and imidazolopyridine RORgt inverse agonists Descriptor: Nuclear receptor ROR-gamma, ~{N}-[8-[[(3~{S})-4-cyclopentylcarbonyl-3-methyl-piperazin-1-yl

Protein Data Bank Japan2024-05-08 更新40

Expression at the mRNA level of markers and cytokines characterizing the Th17 cell subtype in the German acne cohort.

Th17细胞免疫

痤疮分子病理

Expression at the mRNA level of markers and cytokines characterizing the Th17 cell subtype in the German acne cohort.

NIAID Data Ecosystem20

Ras signaling inhibitors in in Adjuvant-induced Arthritis via targeting pathogenic antigen-specific Th17-type cells

自身免疫疾病治疗

Th17细胞免疫

The Ras family of GTPases play an important role in signaling nodes downstream to T cell receptor and CD28 activation, potentially lowering the threshold for TCR activation by autoantigens. Somatic mu

NIAID Data Ecosystem50

Amount of CD4+ T-lymphocyte subpopulation producing IL-17.

Th17细胞免疫

化合物效力评估

aPMA/IONO = 1 µM/10 µM.bAEA = 2.5 µM.cSR1 = 1 µM.dSR2 = 1 µM.eACEA = 1 µM.fJWH = 1 µM.*Denotes pversus CTRL; # denotes pversus PMA/IONO; § denotes pversus PMA/IONO + AEA; Φ denotes pversus PMA/IONO +

Figshare2015-12-02 更新20

Digoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORγt activity

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