Mucosal miRNA expression profiling in ileum of patients with Crohn's disease. Homo sapiens

In this study, we investigated miRNA expression profiles in ileal mucosa from CD patients in different settings (post-operative recurrent (POR) CD, newly diagnosed CD and late stage CD)) and controls. Overall design: Ileal mucosal biopsies were obtained during endoscopy from 35 CD (20 POR (Rutgeerts score ≥i2b), 8 new and 7 late) patients and 8 normal controls. Total RNA, including small RNA, was isolated from ileal mucosal biopsies, labelled and hybridized to Affymetrix Genechip miRNA 2.0 Arrays.