A Facile Route to Polysubstituted Indoles via Three-Component Reaction of 2-Ethynylaniline, Sulfonyl Azide, and Nitroolefin
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https://figshare.com/articles/dataset/A_Facile_Route_to_Polysubstituted_Indoles_via_Three_Component_Reaction_of_2_Ethynylaniline_Sulfonyl_Azide_and_Nitroolefin/2686663
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A copper-catalyzed three-component reaction of 2-ethynylaniline, sulfonyl azide, and nitroolefin is reported. This reaction generates functionalized indoles in good yields and proceeds smoothly under mild conditions. Some hits as an HCT-116 inhibitor are found from the preliminary biological screening.
创建时间:
2016-02-23



