HDX-MS of NicA2 and a NicA2 variant with increased activity

NIAID Data Ecosystem2026-05-01 收录

构象动力学

酶定向进化机制

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https://www.omicsdi.org/dataset/pride/PXD037151 数据链接链接失效反馈

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Here we have used HDX-MS to investigate the change in structure/dynamics in NicA2 and a variant with increased activity (v321) that was generated using directed evolution

创建时间：

2023-11-16

Molecular Simulations Reveal Terminal Group Mediated Stabilization of Helical Conformers in Both Amyloid-β42 and α‑Synuclein

构象动力学

神经退行性机制

The presence of partially structured helices in natively unfolded amyloid-β42 (Aβ42) and α-synuclein (αS) has been shown to accelerate fibrillation in the onset of Alzheimer’s and Parkinson’s disease,

NIAID Data Ecosystem40

Protein Tyrosine Phosphatase 1B Delta helix 7, open state

蛋白质结构解析

构象动力学

Protein Tyrosine Phosphatase 1B Delta helix 7, open state Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GLYCEROL, ... Authors: Choy, M.S, Peti, W, Page, R. Deposit date: 2016-06-

Protein Data Bank Japan2023-09-27 更新20

File S1 - The Effect of Tensile Stress on the Conformational Free Energy Landscape of Disulfide Bonds

构象动力学

分子动力学模拟

Combined Supporting Information file. Figure S1. Macrocycle with the photoswitch, stiff stilbene, in its trans conformation leading to a strained disulfide bond. Figure S2. (a) Probability distributio

Figshare2015-12-02 更新10

Dissecting conformational changes in APP’s transmembrane domain linked to ε-efficiency in familial Alzheimer’s disease

构象动力学

阿尔茨海默病分子机制

The mechanism by which familial Alzheimer’s disease (FAD) mutations within the transmembrane domain (TMD) of the Amyloid Precursor Protein (APP) affect ε-endoproteolysis is only poorly understood. The

NIAID Data Ecosystem30

Molecular dynamics simulations of BmrA starting from X-ray and cryo-EM structure

构象动力学

多药外排蛋白机制

This archive contains all the MD trajectories presented in the article 'Drug-bound and -free outward-facing structures of a multidrug ABC exporter point to a swing mechanism' by Chaptal et al,

Zenodo2021-10-01 更新20

HDX-MS of NicA2 and a NicA2 variant with increased activity

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