Supplemental Materials for "Thyrotrophin receptor antibody: objective and quantitative inflammatory indicator in patients with thyroid eye disease"

These were the supplemental materials for "Thyrotrophin receptor antibody: objective and quantitative inflammatory indicator in patients with thyroid eye disease". The details are as follows: Supplementary Table S1 was demographic and clinical characteristics of 226 TED patients. Supplementary Table S2 was the TRAb levels of TED patients with different clinical characteristics. Supplementary Table S3 was the clinical characteristics in male and female patient cohorts. Supplementary Table S4 was the characteristics of the 41 patients who underwent orbital decompression surgery. Supplementary Table S5 was the expression of 21 cytokines in orbital adipose tissue of TED patients in the TRAb-positive and TRAb-negative cohorts. Supplementary Table S6 was the expression of 27 cytokines in orbital adipose tissue of TED patients in male and female patient cohorts. Supplementary Table S7 was TRAb and CAS in male and female TED patients before and after IVMP therapy. Supplementary Figure S1 was flow chart of participant inclusion assignments. Supplementary Figure S2 was the TRAb levels in the TED patients with different clinical characteristics. Supplementary Figure S3 was the TED patients presented with the 7 CAS items showed higher TRAb level than the patients without the 7 CAS items. Our research shows that there was strong correlation between TRAb and CAS in TED patients. Within TRAb-positive cohorts, pro-inflammatory markers were upregulated, while anti-inflammatory factors showed reciprocal downregulation across. IVMP treatment significantly reduced both TRAb and CAS levels.