Effect of Accelerated Pacing Rates on Exercise Tolerance, Quality of Life and Arrhythmia Burden in Patients with Evidence of Heart Failure with Preserved Ejection Fraction: The PACE-UP Randomised Controlled Trial

This is a dataset of 160 participants (adults aged 35-75 years old) with pacemakers and early HFpEF from Adelaide, South Australia. Participants will be randomised to an accelerated pacing rate (75bpm) or usual care (60bpm), performing follow-up at 4-weeks and 52-weeks post randomisation. The primary outcome is peak oxygen consumption (VO2peak) assessed by cardiopulmonary exercise testing on an upright cycle ergometer, recorded by a metabolic cart, at baseline and then at 52-weeks post-randomisation.