Expanding Monomeric Pyrophosphate Complexes beyond Platinum

Four new monomeric pyrophosphate complexes, namely [Co(phen)2(H2P2O7)]·4H2O (1·4H2O), [Ni(phen)2(H2P2O7)]·8H2O (2·8H2O), [Cu(phen)(H2O)(H2P2O7)] (3) and {[Cu(phen)(H2O)(P2O7)][Na2(H2O)8]}·6H2O (4·14H2O) have been isolated and structurally characterized. The impact of pH and stoichiometry in obtaining 1-4 is described. These complexes have been tested against the adriamycin-resistant ovarian cancer cell line A2780/AD, revealing highly significant (nM) IC50 values, compared to μM IC50 values for cisplatin controls.