TopFIND

TopFIND is a protein-centric database for the annotation of protein termini currently in its third version. Non-canonical protein termini can be the result of multiple different biological processes, including pre-translational processes such as alternative splicing and alternative translation initiation or post-translational protein processing by proteases that cleave proteases as part of protein maturation or as a regulatory modification. Accordingly, protein termini evidence in TopFIND is inferred from other databases such as ENSEMBL transcripts, TISdb for alternative translation initiation, MEROPS for protein cleavage by proteases, and UniProt for canonical and protein isoform start sites.

TopFIND 是一个专注于蛋白质的数据库，用于蛋白质端基的注释，目前处于第三版。非典型蛋白质端基可能源于多种不同的生物过程，包括翻译前过程，如选择性剪接和选择性翻译起始，或翻译后蛋白质加工，由蛋白酶将蛋白酶切割作为蛋白质成熟或调控修饰的一部分。因此，TopFIND 中的蛋白质端基证据是通过其他数据库推断而来，如 ENSEMBL 转录数据库、TISdb 用于选择性翻译起始、MEROPS 用于蛋白酶切割蛋白质，以及 UniProt 用于典型蛋白质和蛋白质同种异构体起始位点。