Cd74

Enables MHC class II protein binding activity; cytokine receptor activity; and nitric-oxide synthase binding activity. Contributes to cytokine binding activity. Involved in several processes, including macrophage migration inhibitory factor signaling pathway; positive regulation of cytokine production; and regulation of signal transduction. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; regulation of T cell differentiation; and thymic T cell selection. Located in several cellular components, including external side of plasma membrane; lysosome; and multivesicular body. Part of MHC class II protein complex; NOS2-CD74 complex; and macrophage migration inhibitory factor receptor complex. Is expressed in lower jaw; lower jaw incisor; lower jaw molar; and thymus primordium. Orthologous to human CD74 (CD74 molecule). [provided by Alliance of Genome Resources, Nov 2024]

该数据集赋予MHC II类蛋白质结合活性、细胞因子受体活性及一氧化氮合酶结合活性；参与细胞因子结合活性的贡献。涉及多种生理过程，包括巨噬细胞迁移抑制因子信号通路、细胞因子产生的正向调控以及信号转导的调节。在抗原加工与通过MHC II类途径呈现外源性肽抗原、T细胞分化的调节以及胸腺T细胞选择等过程中发挥上游作用或位于其中。位于多个细胞组分中，如质膜外侧、溶酶体和多泡体。构成MHC II类蛋白质复合物、NOS2-CD74复合物及巨噬细胞迁移抑制因子受体复合物的一部分。在下颌、下颌门齿、下颌臼齿和胸腺原基中表达。与人类CD74（CD74分子）同源。[由基因组资源联盟提供，2024年11月]