The effect of PDE inhibitors on particulate fractions isolated from <i>P</i>. <i>falciparum</i> parasites.

IC50 values (the concentration of compound that gave 50% inhibition of native PDE activity) are mean ± SEM in μM and were calculated using the Prism software package (GraphPad Software, Inc.). Percentage inhibition data were fitted to a sigmoidal dose-response curve using non-linear regression. Bovine control PDE column displays cAMP dependent activity. All TbPDE1 and most Human values obtained from Kunz, et al.[58]. *Value obtained from Tang, et al.[59]. >200, sufficient inhibition was not observed for an IC50 calculation. Tb: Trypanosama brucei. The effect of PDE inhibitors on particulate fractions isolated from P. falciparum parasites.