NF1 deficiency drives metabolic reprogramming in ER+ breast cancer
收藏NIAID Data Ecosystem2026-05-01 收录
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NF1 deficiency drives metabolic reprogramming in ER+ breast cancer. This reprogramming is characterized by oxidative ATP constraints, glutamine TCA influx, and lipid pool expansion, and these metabolic changes introduce novel metabolic-to-targeted inhibitor synergies. 6 samples derived from the human MCF7 cell line. Cells were grown in DMEM no phenol red + 10% charcoal-stripped FBS + penicillin streptomycin for 3 days and then treated with 10nM beta-estradiol (E2) for 24hr. The samples are divided into 2 genotypes, each with 3 samples. The genotypes are empty vector control (NF1-EV) and NF1 mutant (NF1-45)
创建时间：
2024-02-21
