AMT transfers NH2CH2 from GCSH:SAMDLL to THF

The major degradative pathway for the amino acid glycine is via the glycine cleavage system. In the second reaction in this system, the decarboxylated moiety from glycine decarboxylation attached to H protein (GCSH:SAMDLL) is further degraded by mitochondrial aminomethyltransferase (AMT, GCST, T protein) to ammonia (NH3) and GCSH with reduced lipoate. Tetrahydrofolate (THF) is required for this reaction and accepts the methyl group to form 5,10MTHF (Fujiwara et al. 1984).

甘氨酸这一氨基酸的主要降解途径是通过甘氨酸裂解系统。在此系统中，第二反应中，来自甘氨酸脱羧的脱羧基团与H蛋白（GCSH:SAMDLL）相连，进一步被线粒体氨基甲基转移酶（AMT，GCST，T蛋白）降解为氨（NH3）和还原型脂酰辅酶A（GCSH）。此反应需要四氢叶酸（THF）参与，并接受甲基基团形成5,10-亚甲基四氢叶酸（5,10MTHF）（Fujiwara等，1984年）。