Ubiquitination proteomics reveals epigenetic-energy metabolism mechanisms in senescent ovarian granulosa cells of advanced maternal age

With the help of ubiquitination modified proteomics sequencing, we revealed the differential characteristics of epigenetic ubiquitination modified proteins in granulosa cells between normal reproductive age women and elderly ovarian aging women, and identified the key protein ENO1 in the energy metabolism glycolysis pathway. Its ubiquitination modification and protein degradation may play a role in ovarian aging, providing a new biological basis for studying ovarian aging and improving IVF pregnancy outcomes in elderly women.