Ionizing radiation engages prognostically significant cellular immunity programs in the brain metastasis microenvironment

Brain metastasis (BM) is a deadly end-stage complication of systemic malignancy universally characterized by poor patient prognosis, pointing to the necessity for more effective treatment strategies. Retrospective patient tissue cohorts of breast cancer BM (N=84) and an ongoing clinical trial designed to compare the effectiveness of pre-operative (N=44) and post-operative (N=47) stereotactic radiosurgery (SRS)/stereotactic radiotherapy (SRT) in the management of BM were performed RNA-seq.