RPS19 binding with and without Diamond-Blackfan anemia variants

We found that endogenously expressed RPS19 binds evolutionarily constrained intronic elements. By assessing overexpression of WT RPS19 and RPS19 harboring the most common Diamond-Blackfan anemia missense mutations, we confirmed that disease-relevant mutations alter RPS19 binding preferences in human cells. eCLIP of WT and mutant overexpressed RPS19 in HEK Please note that processed data generated from all replicates is linked to the corresponding *rep1 sample records.