Responsible cell type in murine PAF-induced systemic anaphylaxis

- Platelet-activating factor (PAF) is a key mediator of systemic anaphylaxis.- The principal target cell type of PAF in systemic anaphylaxis remains unclear.- Endothelial cell–specific PAFR-deficient mice were protected from mortality in PAF-induced systemic anaphylaxis.- Endothelial PAFR is suggested to be the principal target mediating PAF-driven mortality in systemic anaphylaxis.