DDIEM

DDIEM is a database of therapeutic approaches to treating IEMs which have been manually extracted from the scientific literature. DDIEM currently covers 300 rare diseases along with the association of 305 genes and 584 drugs that were used to treat these diseases; these treatment attempts have been linked to 1,482 distinct disease-associated phenotypes that were influenced by these treatments. The main entity in DDIEM is the therapeutic procedure which is used to treat a metabolic disorder; these procedures are classified based on their underlying mechanism or modality.DDIEM是一个收录针对先天代谢异常（Inborn Errors of Metabolism，IEM）的治疗方案的数据库，其数据均从科学文献中手动提取得到。目前，DDIEM涵盖300种罕见病，关联了305个用于治疗此类疾病的基因与584种药物；上述治疗尝试与1482种经治疗干预的疾病相关表型建立了关联。DDIEM的核心实体为用于治疗代谢紊乱的治疗操作，此类操作将依据其作用机制或实施方式进行分类。

搜集汇总

背景与挑战

背景概述

DDIEM是一个专注于先天性代谢缺陷治疗方法的数据库，通过手动提取科学文献构建。它涵盖了300种罕见疾病，关联了305个基因和584种药物，并记录了1,482个受治疗影响的疾病表型，治疗方法按机制或模式进行分类。该数据库由KAUST BORG和剑桥大学联合开发，主要用于研究和教育目的。