ObjectiveSeveral studies have demonstrated that compromised blood–brain barrier (BBB) integrity may play a pivotal role in the pathogenesis of individual cerebral small vessel disease (cSVD) markers,
WMH = white matter hyperintensities; OH = orthostatic hypotension; BP = blood pressure; AD = Alzheimer’s disease; APOE = apolipoprotein E.*Mann-Whitney U-test, all other comparisons Chi-Square or Fish
Multivariable logistic regression analyses between possible predictors and old lacunar infarct, cerebral microbleed, and the 3rd tertile enlarged perivascular space.
*Data are presented as the mean ± SD unless otherwise noted; ** p<0.05. T2DM, type 2 diabetes mellitus; BMI, body mass index; HbA1c, glycated hemoglobin; HOMA2-S%, homeostasis model assessment for ins