HVN1940 Metadata Record - The effect of a dairy based protein complex (IDP®) on stress-induced intestinal barrier dysfunction

This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future.Description: Disruption of the intestinal barrier and increased intestinal permeability may play a role in chronic intestinal conditions (such as celiac disease, inflammatory bowel disease, and irritable bowel syndrome), as well as pathological or inflammatory states such as obesity, diabetes and rheumatoid arthritis. In healthy individuals, barrier dysfunction can be caused by a number of stressors including endurance exercise, non-steroidal anti-inflammatory drugs, or dietary factors such as emulsifiers in foods. Increased permeability can lead to an inflammatory cascade that exacerbates the loss of barrier function and, if left unmanaged, can lead to poor digestive or systemic health conditions. However, certain dietary factors may improve barrier permeability by supporting digestive and immune health.This project will investigate whether 14 days of consuming a patented complex of bioactive milk-derived proteins (Immune Defense Proteins (IDP)® ) can mitigate exercise-induced intestinal barrier dysfunction in 18 healthy adults, aged between 18 and 45 years. After 14 days of supplementation with either IDP or a placebo, participants will undertake 20 minutes of high-intensity running before ingesting a sugar solution. Urine will then be collected over 5 hours and analysed for markers of gut permeability. After a 14 day washout, participants will complete the same protocol using the opposite treatment (IDP or placebo).We hypothesise that 14 days of consuming IDP will reduce the increase in intestinal permeability caused by exercise stress in healthy adults.

本元数据记录及其所附文件阐述了作为本研究一部分所收集数据的内容，并制定了该数据当前及未来治理的政策。描述：肠壁屏障的破坏和肠通透性的增加可能在慢性肠道疾病（如乳糜泻、炎症性肠病和肠易激综合症）以及肥胖、糖尿病和类风湿关节炎等病理或炎症状态中发挥一定作用。在健康个体中，屏障功能障碍可能由多种应激因素引起，包括耐力运动、非甾体抗炎药或食品中的乳化剂等饮食因素。通透性的增加可能导致炎症级联反应，加剧屏障功能的丧失，若未得到有效管理，可能引发消化系统或全身健康状况的恶化。然而，某些饮食因素可能通过支持消化和免疫功能来改善屏障通透性。本研究旨在探讨连续14天摄入一种专利生物活性乳蛋白复合物（免疫防御蛋白（IDP®））是否能够减轻18名18至45岁健康成人运动引起的肠壁屏障功能障碍。在服用IDP或安慰剂14天后，参与者将进行20分钟的高强度跑步，随后摄入糖溶液。随后，将在5小时内收集尿液，并分析肠道通透性的标志物。在14天的清洗期后，参与者将使用另一种治疗（IDP或安慰剂）完成相同的方案。我们假设，连续14天摄入IDP将减少健康成人运动应激引起的肠通透性增加。