Mitochondrial-to-nuclear communication in aging: an epigenetic perspective
收藏中国科学院中国科学技术大学科学数据中心2026-01-10 收录
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资源简介：
Age-associated changes in mitochondria are closely involved in aging. Apart
from the established roles in bioenergetics and biosynthesis, mitochondria are
signaling organelles that communicate their fitness to the nucleus, triggering
transcriptional programs to adapt homeostasis stress that is essential for organismal health and aging. Emerging studies revealed that mitochondrial-to-nuclear
(mito-nuclear) communication via altered levels of mitochondrial metabolites or
stress signals causes various epigenetic changes, facilitating efforts to maintain
homeostasis and affect aging. Here, we summarize recent studies on the mechanisms by which mito-nuclear communication modulates epigenomes and their
effects on regulating the aging process. Insights into understanding how mitochondrial metabolites serve as prolongevity signals and how aging affects this
communication will help us develop interventions to promote longevity and
health.
提供机构：
中国科学院遗传与发育生物学研究所
创建时间：
2023-10-21
