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FeCl3‑Mediated Synthesis of β‑Alkynyl Ketones via Domino Nucleophilic-Substitution/Intramolecular-Cyclization/Reverse Claisen Condensation of N‑Cyclohexyl Propargylamines and 1,3-Diketones

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Figshare2016-02-13 更新2026-04-29 收录
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https://figshare.com/articles/dataset/FeCl_sub_3_sub_Mediated_Synthesis_of_Alkynyl_Ketones_via_Domino_Nucleophilic_Substitution_Intramolecular_Cyclization_Reverse_Claisen_Condensation_of_i_N_i_Cyclohexyl_Propargylamines_and_1_3_Diketones/2170609
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资源简介:
The synthesis of β-alkynyl ketones was achieved in good to excellent yields by an iron-catalyzed domino reaction of N-cyclohexyl propargylamines and 1,3-diketones. A plausible mechanism involving nucleophilic substitution, intramolecular cyclization, and reverse Claisen condensation for this process is proposed.
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2016-02-13
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