FeCl3‑Mediated Synthesis of β‑Alkynyl Ketones via Domino Nucleophilic-Substitution/Intramolecular-Cyclization/Reverse Claisen Condensation of N‑Cyclohexyl Propargylamines and 1,3-Diketones
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The synthesis of β-alkynyl ketones was achieved in good to excellent yields by an iron-catalyzed domino reaction of N-cyclohexyl propargylamines and 1,3-diketones. A plausible mechanism involving nucleophilic substitution, intramolecular cyclization, and reverse Claisen condensation for this process is proposed.
创建时间:
2016-02-13



