Gene expression analysis of breast tumours from dormant and acquired resistant patients

Sequential patient-matched samples treated with extended neoadjuvant therapy were studied. Long-term treatment (letrozole) induced changes in dormant and resistant patients were determined. Samples were classified as pre-treatment (timepoint1, <0 days), early-on treatment (timepoint2, 0-120 days) and long-term treatment (timepoint4, >120 days). A total of 101 samples from 39 patients were processed. Data was analysed with two previously generated datasets, GSE59515 (14 patients, 42 samples) and GSE55374 (9 patients, 24 samples) which were also processed on Illumina HT-12v4 BeadChips (GPL10558).