Effect of sodium hydrosulfide on gene expression of intestinal epithelial cells

The transcriptome sequencing was used to study effects of H2S on the intracellular processes in human colon carcinoma cell line Caco-2. The results establish that excessive H2S increased the expression of genes related to inflammatory response, provoked oxidative stress, weakened mitochondrial function and strengthened mitophagy and autophagy. Examinations of sodium hydrosulfide on gene expression of normal and inflammatory Caco-2 cells