SP140 functional variant associated with Multiple Sclerosis and Inflammatory Bowel Disease up-regulates inflammatoy response.

With this project we aimed to explain why the reduction of SP140 expressionassociates with susceptibility to MS, CD and IBD. Lymphoblastoid cell line(NA07000) was transfected with siRNA-SP140 or siRNA control by triplicate.Cells were harvested 48 hours after transfection and RNA extracted