Photoactivatable aryl amide substituted fatty acid protonophores
收藏Taylor & Francis Group2025-11-26 更新2026-04-16 收录
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https://tandf.figshare.com/articles/dataset/Photoactivatable_aryl_amide_substituted_fatty_acid_protonophores/29991577/1
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资源简介：
Aryl amide substituted fatty acids facilitate transmembrane proton transport and uncouple mitochondrial oxidative phosphorylation in cells, leading to cell death. Photocaging is a potential strategy to enable light-controlled activation of mitochondrial uncouplers with spatio-temporal control. In this work, aryl amide substituted fatty acid protonophores were photocaged with <i>ortho</i>-nitrobenzyl and 4,5-dimethoxy-2-nitrobenzyl groups. The caged protonophores could be activated by irradiation with UV light, demonstrated in vesicular transport assays and in vitro against MDA-MB-231 breast cancer cells.
提供机构：
Pacchini, Ethan; Ryder, William G.; Gale, Philip A.; York, Edward; Rajasekar, Sherly; Gertner, David S.; McNaughton, Daniel A.; Rawling, Tristan; Lockwood, Thomas E.
创建时间：
2025-08-26
