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An autoimmune disease risk variant has a trans master regulatory effect mediated by IRF1 under immune stimulation

NIAID Data Ecosystem2026-03-11 收录

自身免疫疾病遗传学

免疫刺激转录调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE145487 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2020-02-19

自身免疫疾病遗传学

临床试验分子标记物发现

In a clinical trial for anti-IL-6 in patients with systemic lupus erythematosus we measured interferon (IFN) status, anti-IL-6 drug exposure and genome-wide gene expression at three time points (379 s

Figshare2023-05-31 更新50

A Comparison of Assays for Accurate Copy Number Measurement of the Low-Affinity Fc Gamma Receptor Genes FCGR3A and FCGR3B

基因拷贝数变异

自身免疫疾病遗传学

The FCGR3 locus encoding the low affinity activating receptor FcγRIII, plays a vital role in immunity triggered by cellular effector and regulatory functions. Copy number of the genes FCGR3A and FCGR3

NIAID Data Ecosystem40

Frequency of PTPN22 of protective allele (A788) in Caucasian ANCA patients.

自身免疫疾病遗传学

ANCA相关血管炎

Frequency of PTPN22 of protective allele (A788) in Caucasian ANCA patients.

Figshare2015-12-02 更新00

Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis

自身免疫疾病遗传学

HLA蛋白质功能预测

Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease characterised by progressive destruction of intrahepatic bile ducts. The strongest genetic association is with HLA-DQA1*04:01, b

NIAID Data Ecosystem40

Additional file 2 of Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans

自身免疫疾病遗传学

HLA等位基因关联分析

Additional file 2. Dataset 1. Meta-analysis results data table of suggestive SNPs (-log10(p) > 5.0).

Figshare2021-05-20 更新40