Real-time VIM thalamus recordings during peripheral nerve stimulation treatment for essential tremor: DBS intraoperative dataset

Background: Essential tremor (ET), the most common movement disorder in adults, presents with involuntary shaking of the upper extremities during postural hold and kinetic tasks linked to dysfunction in the cerebellothalamo-cortical network. Recently, transcutaneous afferent patterned stimulation (TAPS), applied through a wrist-worn device, has emerged as a non-invasive treatment for medication-refractory ET. However, its mechanism remains unclear.
Objective: We hypothesize that TAPS reduces tremors through modulation of the VIM thalamus in the cerebellothalamo-cortical network.
Methods: Employing refractory pure ET patients seeking VIM deep brain stimulation (DBS), we quantified clinical tremor improvement following TAPS treatment in a pre-operative setting, followed by intra-operative microelectrode recording of the contralateral thalamus with concurrent TAPS treatment on and off.
Results: After one preoperative session, TAPS significantly reduces upper limb tremor average (0.61, p = ..., , , ## Real-time VIM thalamus recordings during peripheral nerve stimulation treatment for essential tremor: DBS intraoperative dataset

This codebase contains processed microelectrode recordings (MER) from human subjects with essential tremor, along with analysis scripts used to generate the findings published in [Luu et al., 2025](https://doi.org/10.1016/j.brs.2025.06.004).

## Human Subject Study

**Study identifier:** CH1052\
**Number of subjects:** 9 (numbered 02, 03, 06-12)\
**Condition:** Essential tremor\
**Intervention:** Transcutaneous afferent patterned stimulation (TAPS)\
**Recording context:** Intra-operative microelectrode recordings during deep brain stimulation (DBS) surgery

## Getting Started

```
Repository/
├── E-Files/
│ ├── E-CH1052-02.mat
│ ├── E-CH1052-03.mat
│ ├── E-CH1052-06.mat
│ ├── E-CH1052-07.mat
│ ├── E-CH1052-08.mat
│ ├── E-CH1052-09.mat
│ ├── E-CH1052-10.mat
│ ├── E-CH1052-11.mat
│ ├── E-CH1052-12.mat
│ └── stimVbase.mat
├── P-Files/
│ ..., All protected health information (PHI) has been purged from the metadata. Informed consent was obtained from all subjects to publish de-identified data in accordance with approved Institutional Review Board protocol.