Gene Expression Analysis of NK cells after co-culture with Liver Sinusoidal Endothelial Cells (LSECs)

The liver is enriched in innate lymphocytes, including Natural Killer (NK) cells, that can continuously interact with Liver Sinusoidal Endothelial Cells (LSECs) within liver sinusoids. NK cells provide the early defence against infections and malignancies by exerting cytotoxicity and by secreting pro-inflammatory cytokines. To decipher how LSECs affect NK cell phenotype and function, we co-cultured NK cells with LSECs and used microarray technology to identify transcriptomic changes. co-cultured NK cells with LSECs Please note that the chips used are 'Clariom D Mouse', previously labeled as GeneChip Mouse Transcriptome Array (MTA) but later changed to 'Clariom_D_Mouse', and thus the chp information (included in the CEL files, generated before renaming) reads MTA-1_0.