Replication of previously reported associations.

SNPs were taken from the PDGene “Top Results” list of meta-analyses [27] and the NHGRI list of associations [57]. Alleles are given with respect to the forward genomic strand for NCBI build 36.3 and are listed as major/minor. Where a proxy SNP was used, alleles refer to the proxy SNP. Published OR is the published odds ratio per copy of the minor allele for the association, as reported in the corresponding reference. Overall grades for SNPs based on the Venice criteria [72] were taken from the PDGene list, where available, and omitted otherwise. “NR” means that an OR or CI was not reported. -values and power calculations were calculated assuming a two-sided test. Our power to replicate a given association conditional on the published odds ratio and the minor allele frequency using a 0.05 threshold for significance was above 86% for all associations except for rs10200894, for which it was 59%. “Pop” refers to the ancestry in which the association was discovered, as taken from the PDGene list or the original paper where applicable. “All” indicates that multiple studies were used in the PDGene meta-analysis, irrespective of ancestry.