Impact of the expression levels of intratumoral DPD ((A) DPD protein expression and (B) DPD mRNA expression) on disease-free survival.

(A) Clinical variables that had P < 0.10 in univariate analyses on DFS (age [< 60 years vs. 60–69 years vs. ≥ 70 years], surgical method [laparoscopic vs. open], lymphatic invasion [no vs. yes], venous invasion [no vs. yes], stage [IB/II vs. III], DPD IHC score [≥ 10 vs. < 10] and TP IHC score [0 vs. > 0]) were included in this multivariate analysis using a Cox proportional hazards model. A backward stepwise conditional regression was used with P = 0.10 as the entry and P = 0.10 as the removal criteria. Abbreviations: IHC, immunohistochemistry; DPD, dihydropyrimidine dehydrogenase; TP, thymidine phosphorylase.
(B) Clinical variables that had P < 0.10 in univariate analyses on DFS (age [< 60 years vs. 60–69 years vs. ≥ 70 years), surgical method [laparoscopic vs. open], lymphatic invasion [no vs. yes], venous invasion [no vs. yes], stage [IB/II vs. III]) and mRNA expression levels of DPD gene were included in this multivariate analysis using a Cox proportional hazards model. A backward stepwise conditional regression was used with P = 0.10 as the entry and P = 0.10 as the removal criteria.
Impact of the expression levels of intratumoral DPD ((A) DPD protein expression and (B) DPD mRNA expression) on disease-free survival.