Dataset for Mathematical Model of in vitro Hepatocellular Cholesterol and Lipoprotein Metabolism, fig. 2
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Comparison of numerical simulations conducted with the original model from [18] and with the newly developed model including PCSK9. In the latter, the concentration of PCSK9 in the extracellular space was 10<sup>12</sup> molec./mL. The initial oscillations in mRNA and molecular levels, as well as the steady-state levels are reproduced well. The slow kinetics of VLDL and LDL extraction from the extracellular environment are also captured.<br>
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2022-01-28
