Gene expression profiling of isogenic malignant melanoma A375-BRAFV600E/NRASQ61 and A375-BRAFV600E/NRASQ61K cell lines
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE184633
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资源简介：
BRAF-inhibitor (BRAFi)-resistance compromises long term survivorship of malignant melanoma patients, and mutant NRAS is a major mediator of BRAFi-resistance. We have employed NanoString nCounterTM transcriptomic analysis of isogenic human malignant melanoma cells that differ only by NRAS mutational status (BRAFi-sensitive A375-BRAFV600E/NRASQ61 versus BRAFi-resistant A375-BRAFV600E/NRASQ61K), identifying modulation of specific gene expression networks as a function of NRASQ61K-status. Differential expression between isogenic human malignant melanoma A375-BRAFV600E/NRASQ61 (n=3) and A375-BRAFV600E/NRASQ61K (n=3) cell lines was assessed using nCounter PanCancer Panel code set.
创建时间：
2021-12-23
